Home / CASE FINDING INFEKSI KUSTA SUBKLINIS PADA ANAK MELALUI DETEKSI KADAR ANTIBODI IgM ANTI PGL-1

CASE FINDING INFEKSI KUSTA SUBKLINIS PADA ANAK MELALUI DETEKSI KADAR ANTIBODI IgM ANTI PGL-1

Arif Sujagat, Fardhiasih Dwi Astuti, Eva Muslimawati Saputri, Annisa Sani, Agil Dwi
Prasetya
Fakultas Kesehatan Masyarakat, Universitas Ahmad Dahlan
Alamat korespondensi :
Jln. Prof. Dr. Soepomo, Janturan, Yogyakarta 55164
Email: jagat.arif2011@gmail.com
ABSTRACT
Leprosy is a chronic infectious disease caused by mycobacterium leprae. In 2012 until 2014, Indonesia has the third biggest leprosy cases in the world. Surabaya was leprosy endemic areas. The research aimed to early detection subclinical leprosy infection based on measurement antibodies levels (IgM) anti PGL-1 and analize factors that influence subclinical leprosy infection for childrens in Surabaya. The research study was analitic observational with cross-sectional design. The study population was a family members who had leprosy patients. Samples was selected simple random sampling and 30 KK selected by rapid school survey and village survey in April-May 2015. Data was collected by interview used questionnaire. Specimens was taken from peripheral blood of fingertip
used a capillary tube and filter paper method. Serological test in Leprosy Laboratory of Institute of Tropical Diseases Unair to determine levels of antibodies specific leprosy by ELISA method. Results of seropositives set cut off point ≥ 245 u/ml is subclinical leprosy. Result of serological test showed 8 respondents (26,7%) was positive subclinical leprosy. Analize result by chi-square showed contact history (p value 0,034; RP 4,500) and duration of contact (p value 0,028; RP 5,182) were factors that influence subclinical leprosy infection for childrens. Serological test antibodies levels IgM anti PGL-1 used in screening program to subclinical leprosy.
Keywords: IgM, Antibodies specific leprosy, subclinical leprosy